Nanostructured Lipid Carriers (NLCs) + Short Peptides — Dual-action delivery to repair hair exactly where it's needed.
The video showcases the key steps in the formulation process: melting of the three oils, uniform emulsification, ice-bath ultrasonic nanosizing, and low-temperature solidification. The nano-carrier then penetrates damaged hair strands, slowly releasing short peptides that bind with keratin to flatten cuticles and restore smoothness and shine.
01
Melt and Blend
Three vegetable oils are thermally melted, and short peptides are dispersed into the oil phase.
02
Emulsify and Sonicate
Homogenize uniformly, then sonicate under ice bath to produce nanoparticles.
03
Cold Solidification
Solidify and shape by ice bath incubation to obtain the NLC-encapsulated short peptide formulation.
04
Deliver & Release
Carrier integrates into hair strands; short peptides release slowly and bind with keratin to repair.
The brand concept video, generated by AI, demonstrates the preparation and repair mechanism of NLC-encapsulated short peptides.
Based on research published in Acta Biomaterialia, we designed the biomimetic short peptide PepACS using bioinformatics and fused it with the red fluorescent protein mCherry to create PepACS-mCh. Upon cleavage at a specific site, PepACS repairs hair damage while mCherry enhances hair shine.
PepA · PepC · SPB · Repair Support
Cysteine-rich biomimetic peptides that interact with keratin thiols in situ, restructure disulfide bonds, repair cuticle damage, and preserve hair mechanical properties.
Red Fluorescent Protein · Radiance Hero
Preserves the complete folded structure and red fluorescence, forming a uniform optical color layer on each strand for richer, fuller shine.
32.96 kDa
Fusion Protein Molecular Weight (Verified by NanoLC-ESI-MS/MS)
49 aa
PepACS peptide length, including two rigid linkers
E. coli BL21
Synthetic Biology Biosynthetic Expression System
CCK-8
Cell assays demonstrated excellent biocompatibility.
Content adapted from Fan C., Shi J., et al. Bioinspired peptides designed for hair perming and dyeing with potential for repair. Acta Biomaterialia, 2023.
The oil phase is not just a base—it's part of the delivery system. Three plant oils form a protective barrier on the hair surface to lock in moisture, reducing dryness and frizz. Coconut oil penetrates deep into the hair cortex, working synergistically with short peptide actives.
Argan oil
Nourish hair surfaces with unsaturated fatty acids to help resist external oxidative stress and deliver a soft, silky touch.
Castor Oil
Ricinoleic acid provides gentle antimicrobial properties and helps form a uniform protective film on the hair surface.
Coconut Oil
Small-molecule lipids penetrate deep into the hair cortex to improve dryness and frizz from within.
SYNERGY · Collaboration Mechanism
Fatty acids carry a negative charge and bind with positively charged short peptides to form oil-in-water liposomes. The oil phase has high affinity for hair fibers, gradually penetrating them to slowly release the peptides within the hair shaft, thereby extending the duration of the repair effect.
01
Nanostructured lipid carriers (NLC) use natural lipids as a base to gently encapsulate short peptide actives, preserving their stability and activity.
02
Lipid affinity enables the carrier to penetrate the cuticle barrier and deliver short peptides to damaged areas within the hair shaft, rather than remaining on the surface.
03
Short peptides rebuild bonds at damaged sites, working with lipid replenishment to restore hair's smoothness, shine, and strength.
Under macroscopic lab observation, damaged cuticles appear lifted and fractured. After treatment with the NLC-peptide system, hair surfaces become smooth and even, with enhanced shine. Our goal is to restore hair to its natural order.
MID-TIER · Mid-range
Keratin Peptide Repair
Keratin short peptide repair line for daily coloring and perming care. Delivers keratin-derived peptides via NLC to maintain hair structure integrity and everyday shine. Ideal for salon treatments and at-home maintenance.
PREMIUM
Active Composite Serum
A multi-actives serum designed for severe damage and premium care. Featuring a higher concentration of short peptides delivered deep via NLC technology, it provides intensive structural repair for heavily colored or chemically treated hair.
Comparison with mainstream commercial repair mechanisms (✓ = Available / — = Not Available)
| Mechanism Dimension | NLC-ACS | Olaplex | K18 | Hair Mask |
|---|---|---|---|---|
| Short peptide actives | ✓ | — | ✓ | — |
| Structural Keratin Repair | ✓ | ✓ | ✓ | ✓ |
| NLC Nano-Drug Delivery | ✓ | — | — | — |
| Natural lipid base | ✓ | — | — | ✓ |
| Gentle Cleansing Formula | ✓ | — | ✓ | ✓ |
| No secondary cleaning required | ✓ | — | ✓ | — |
Comparison data is compiled from publicly available product information and brand R&D assessments. NLC-ACS is currently in the development phase.
The core team's research has been published in international academic journals, and a patent application for NLC-based peptide encapsulation technology has been filed.
Acta Biomaterialia · 2023
Biomimetic Peptide Design for Heat and Color Damage Repair
Changxin Fan, Jiacheng Shi, Xin Wei, Ziqi Xie, Mingyuan Cheng, Xinghong Cao, Yu Zhou, Yi Zhan, Yunjun Yan
Acta Biomaterialia, Vol. 168, 440–457
View Original DOIBiomedicines · 2026
A Review of Short Peptides in the Field of Hair Loss Prevention
Changxin Fan, Yanyu Chen, Qinghua Huang, Wai Ying Ou, Cancan Zhang, Yanlin Sun, Tianyue Wu, On Yee Leung, Hei Ching Iu, Jiacheng Shi
Biomedicines, 2026, 14(4), 864
View Original DOIPATENT · Invention Patent
Preparation and Method for Nanostructured Lipid Carrier-Encapsulated Protein Polypeptide
Patent information is based on public data from the China National Intellectual Property Administration; paper information is sourced from official journal websites.
